0704-883-0675     |      dataprojectng@gmail.com

SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

The aim of this study was to enhance the solubility and hence dissolution rate of two poorly soluble drugs: ibuprofen and piroxicam using Eudragit RS 100 and hydroxymethylpropylcellulose (HPMC) as carriers, by solid dispersion technique and to evaluate the effect of trona (sodium sesquicarbonate) on the dispersions . Solid dispersions of ibuprofen and piroxicam were prepared using HPMC or Eudragit RS 100 and their combinations by the solvent evaporation method. The prepared dispersions were characterized with respect to drug content, production yield, moisture sorption and desorption, Fourier Transform Infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). The solubilities of the pure drug, solid dispersions and their physical mixtures were studied using standard method. In vitro drug release of ibuprofen and piroxicam from the solid dispersions was evaluated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes in a sequential fashion. Antiinflammatory effects of the solid dispersions were investigated in comparison to the pure drug using the egg albumin induced paw odema in rats. Stability studies at 75% relative humidity and room temperature (28oC) was carried out on the prepared solid dispersions. Results indicate that the solid dispersions with HPMC entrapped greater amount of drug in comparison to those with Eudragit RS 100. Moisture sorption studies indicate the amorphous state of drugs in the solid dispersions. Solubility studies revealed marked increase in solubility of drugs from solid dispersions when compared to pure drugs and physical mixtures. Solid dispersions of ibuprofen with HPMC containing 1:2 drug : polymer ratio had 8 fold increase in solubility when compared to pure drug . Solid dispersions of piroxicam with Eudragit and HPMC (ratio 0.1:1:1) gave a 3 fold increase in solubility when compared to the pure drug. Solid dispersion of the drugs with HPMC gave a faster drug release in simulated gastric fluid while Eudragit RS 100 based solid vii dispersions exhibited a delayed release of ibuprofen in the fluid. Solid dispersions of piroxicam incorporating trona showed enhanced solubility and dissolution when compared to dispersions without it, but trona was seen to decrease solubility and dissolution of ibuprofen. The FT-IR spectroscopic studies revealed that there was no chemical interaction between the drug and the polymers, while the DSC scans showed changes from crystalline to amorphous form of the drug. Solid dispersions were seen to have enhanced anti-inflammatory effect relative to the pure drug. Stability studies of these solid dispersions revealed that the formulations were stable.




FIND OTHER RELATED TOPICS


Related Project Materials

THE CHALLENGES OF ACCOUNTING FOR FINANCIAL INSTRUMENTS IN PUBLIC ACCOUNTING

THE CHALLENGES OF ACCOUNTING FOR FINANCIAL INSTRUMENTS IN PUBLIC ACCOUNTING

The study's objectives are to: 1) Identify the challenges...

Read more
MANAGEMENT AND CONTROL OF INVENTORY IN GOVERNMENT HEALTH INSTITUTION

Abstract

Managing stock effectively is important for any organization, running a hospital is no exception because withou...

Read more
EFFECTS OF MOBILE PHONE USAGE ON ACADEMIC PERFORMANCE OF STUDENTS

ABSTRACT

This research work was aimed at finding out the Effects of Mobile Phone Usage on Academic Performance of St...

Read more
MARKETING STRATEGIES AS A TECHNIQUE FOR PROFIT MAXIMIZATION IN MANUFACTURING ENTERPRISE

ABSTRACT

This research examined marketing strategies as techniques for profit maximization in a manufacturing enterprise (A survey of Gui...

Read more
SECURITY CHALLENGES IN NIGERIA AND THE IMPLICATIONS FOR BUSINESS ACTIVITIES AND SUSTAINABLE DEVELOPMENT

ABSTRACT

The study examined the insecurity situation in Nigeria and its implications for business investment, opera...

Read more
DESIGN AND IMPLEMENTATION OF AN INTERACTIVE ONLINE PLATFORM FOR STUDENTS AND SCHOOL SUPERVISORS TO COMMUNICATE REGULARLY DURING THE STUDENTS IT/SIWES ATTACHMENT.

BACKGROUND OF THE STUDY

The Students Industrial Work Experience Scheme (SIWES) is a skills training programme designed t...

Read more
CAR AND CHAUFFEUR HIRING SERVICES.

ABSTRACT

      This application presents an application (on the design and implementation) for...

Read more
TAX AS A STIMULUS FOR GROWTH AND DEVELOPMENT IN NIGERIA

ABSTRACT

Taxation and its product, Tax have been very important vehicles for  eco...

Read more
ACCOUNTING INFORMATION AS A TOOL FOR MANAGEMENT DECISION MAKING  

ABSTRACT

  This research work highlights the result of a research carried out to examine the relevance of accounting information to...

Read more
ENVIRONMENTAL DEGRADATION AND OIL SPILLAGES: AN INDICTMENT TO ENVIRONMENTAL LAW AND HUMAN RIGHTS

    1. Environmental Degradation

Before environmental degradation is considered...

Read more
Share this page with your friends




whatsapp